In every century people have thought they understood the Universe at last, and in every century they were proven to be wrong. It follows that the one thing we can say about out modern "knowledge" is that it is wrong.
Socrates had said on learning that the Delphic oracle had proclaimed him the wisest man in Greece. "If I am the wisest man," said Socrates, "it is because I alone know that I know nothing."
The basic trouble, you see, is that people think that "right" and "wrong" are absolute; that everything that isn't perfectly and completely right is totally and equally wrong.
Let me dispose of Socrates because I am sick and tired of this pretense that knowing you know nothing is a mark of wisdom. No one knows nothing. In a matter of days, babies learn to recognize their mothers. Socrates would agree, of course, and explain that knowledge of trivia is not what he means. He means that in the great abstractions over which human beings debate, one should start without preconceived, unexamined notions. Now where do we get the notion that "right" and "wrong" are absolutes? Young children learn spelling, for instance, and here we tumble into apparent absolutes. How do you spell "sugar?" Suppose Alice spells it p-q-z-z-f and Genevieve spells it s-h-u-g-e-r. Both are wrong, but is there any doubt that Alice is more wrong than Genevieve? When people thought the Earth was flat, they were wrong. When people thought the Earth was spherical, they were wrong. But if you think that thinking the Earth is spherical is just as wrong as thinking the Earth is flat, then your view is more wrong than both of them put together.
Source: Relativity of Wrong: Essays on Science by Isaac Asimov